In a study of people taking tirzepatide, people who were switched to a placebo gained back 14% of the 25.5% of their lost body weight (the placebo group continued to receive coaching). It’s not necessarily unexpected, though:

“If a patient wants to go off the medicine, we’ll try. But we also say what the results are — so far, it seems like most people are going to gain weight back,” Dr. Jay said. “And that’s not your fault. That’s because obesity is a disease, and this medicine is helping to address it.”

How Much Weight Comes Back After You Stop Using a Weight-Loss Drug?